[Bone and Nutrition. Functional foods for bone and cartilage tissues : Evidence for the action of collagen peptides]

Yoshifumi Kimira; Hiroshi Mano

[Bone and Nutrition. Functional foods for bone and cartilage tissues : Evidence for the action of collagen peptides]

Clin Calcium. 2015 Jul;25(7):1007-14.

[Article in Japanese]

Authors

Yoshifumi Kimira¹, Hiroshi Mano

Affiliation

¹ Department of Clinical Dietetics and Human Nutrition, Faculty of Pharmaceutical Sciences, Josai University, Japan.

PMID: 26119313

Abstract

Collagen peptides, including glucosamine, are well-known functional food materials that act on bone and cartilage tissues. Collagen peptides are used at a volume of about 6,000 tons per year as a raw material in Japan. Evidence for the action of collagen peptides for both bone and cartilage tissues has accumulated both at basic research level (in vivo and in vitro ) and clinically. To confirm the clinical effect of these peptides and clearly identify their mechanism of action at the molecular level, further clinical studies comprising disease-free subjects, alongside basic research studies, are required.

Publication types

English Abstract
Review

MeSH terms

Animals
Bone Density / drug effects
Bone and Bones / cytology
Bone and Bones / metabolism*
Cartilage / cytology
Cartilage / metabolism*
Cell Differentiation / drug effects
Cell Differentiation / genetics
Cell Proliferation / drug effects
Cell Proliferation / genetics
Chondrocytes / cytology
Collagen* / chemistry
Collagen* / metabolism
Collagen* / pharmacology
Functional Food*
Gene Expression Regulation, Developmental / drug effects
Humans
Hydroxyproline
Osteoblasts / cytology
Osteoporosis / metabolism
Osteoporosis / prevention & control
Peptide Fragments* / chemistry
Peptide Fragments* / metabolism
Peptide Fragments* / pharmacology
Proline
Rats

Substances

Peptide Fragments
Collagen
Proline
Hydroxyproline