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J Affect Disord. 2015 Sep 15;184:245-8. doi: 10.1016/j.jad.2015.05.067. Epub 2015 Jun 16.

Serum levels of nerve growth factor (NGF) in patients with major depression disorder and suicide risk.

Author information

1
Programa de Pós-Graduação em Saúde e Comportamento, Centro de Ciências da Vida e da Saúde, Universidade Católica de Pelotas, Av. Gonçalves Chaves 373, 96015-560 Pelotas, RS, Brasil.
2
Programa de Pós-Graduação em Biologia Celular e Molecular Pontifícia Universidade do Rio Grande do Sul, Av. Ipiranga 6681, 90619-900 Porto Alegre, RS, Brasil.
3
Programa de Pós-Graduação em Ciências Biológicas: Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Av. Ramiro Barcelos 2600, 90035-000 Porto Alegre, RS, Brasil.
4
Programa de Pós-Graduação em Saúde e Comportamento, Centro de Ciências da Vida e da Saúde, Universidade Católica de Pelotas, Av. Gonçalves Chaves 373, 96015-560 Pelotas, RS, Brasil. Electronic address: jean.pierre.oses@gmail.com.

Abstract

Nerve growth factor (NGF) is an important member of the neurotrophins group and their involvement in the pathophysiology of major depression disorder (MDD) and suicide risk (SR) has been recently suggested. The aim of this study is to evaluate the changes in NGF serum levels in individuals with MDD and with or without risk of suicide, in subjects from a young population-based sample. This is a paired cross-sectional study nested in a population-based study. Individuals were rated for MDD and SR by a diagnostic interview--Mini International Neuropsychiatric Interview (M.I.N.I). The total population of the sample was comprised of 141 subjects distributed in three groups: 47 healthy controls, 47 subjects with current depressive episode without SR (MDD) and 47 subjects with current depressive episode and with SR (MDD + SR). NGF serum levels were significantly reduced in the MDD and MDD + SR groups when compared with controls (p ≤ 0.001). However, there were no differences in NGF levels between the MDD and MDD + SR groups (p = 1.000). These results suggest that reduced NGF serum levels can be a possible biomarker of MDD.

KEYWORDS:

Major depressive disorder; Nerve growth factor; Suicide risk

PMID:
26118751
DOI:
10.1016/j.jad.2015.05.067
[Indexed for MEDLINE]

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