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J Med Virol. 2016 Jan;88(1):120-6. doi: 10.1002/jmv.24313. Epub 2015 Jul 16.

Risk of congenital disease in 46 infected fetuses according to gestational age of primary human cytomegalovirus infection in the mother.

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Department of Microbiology and Virology, Molecular Virology Unit, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
Departments of Obstetrics and Gynecology, "V.Buzzi" Hospital, ICP, University of Milan, Milan, Italy.
Obstetric and Gynecology Unit, Fondazione IRCCS Ospedale Maggiore Policlinico di Milano, Milan, Italy.
Neonatology and Neonatal Intensive Care Unit, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
Department of Clinical, Section of Microbiology, Surgical, Diagnostic, and Pediatric Sciences, University of Pavia, Pavia, Italy.


Given the difficulty in establishing the exact time of HCMV transmission from mother to fetus, HCMV intrauterine infection was investigated in 46 infected fetuses/newborns by correlating maternal and fetal parameters with clinical outcome according to the time interval between the onset of maternal infection and prenatal diagnosis. In detail, 17/28 (60.7%) asymptomatic and 18/18 (100%) symptomatic fetuses/newborns were infected as a consequence of a primary maternal HCMV infection acquired ≤8 weeks of gestational age, while 11/28 (39.3%) asymptomatic and 0/18 (0%) symptomatic fetuses/newborns were congenitally infected when maternal infection was acquired >8 weeks' gestation. Symptomatic fetal infections appeared to be associated with a maternal primary infection occurring at ≤ 8 weeks' gestation. Cordocentesis performed at 20 weeks' gestation should be restricted to high risk infected fetuses.


amniocentesis; congenital disease; human cytomegalovirus; maternal infection

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