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Trends Neurosci. 2015 Aug;38(8):486-95. doi: 10.1016/j.tins.2015.05.006. Epub 2015 Jun 24.

Attention: the claustrum.

Author information

1
Department of Biological Chemistry, Institute of Life Sciences, Faculty of Natural Sciences, The Hebrew University, Jerusalem, Israel.
2
Edmond and Lily Safra Center for Brain Sciences, The Hebrew University, Jerusalem, Israel.
3
Department of Biological Chemistry, Institute of Life Sciences, Faculty of Natural Sciences, The Hebrew University, Jerusalem, Israel; Edmond and Lily Safra Center for Brain Sciences, The Hebrew University, Jerusalem, Israel. Electronic address: ami.citri@mail.huji.ac.il.

Abstract

The claustrum is a mysterious thin sheet of neurons lying between the insular cortex and the striatum. It is reciprocally connected with almost all cortical areas, including motor, somatosensory, visual, auditory, limbic, associative, and prefrontal cortices. In addition, it receives neuromodulatory input from subcortical structures. A decade ago, Sir Francis Crick and Christof Koch published an influential review proposing the claustrum as the 'seat of consciousness', spurring a revival of interest in the claustrum. We review the literature on the claustrum, emphasizing recent discoveries, and develop a detailed hypothesis describing a role for the claustrum in the segregation of attention.

KEYWORDS:

attention; bottom up; claustrum; cortex; sensory modalities; top down

PMID:
26116988
DOI:
10.1016/j.tins.2015.05.006
[Indexed for MEDLINE]

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