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Clin Plast Surg. 2015 Jul;42(3):353-64, viii-ix. doi: 10.1016/j.cps.2015.03.009.

Regenerative Approach to Scleroderma with Fat Grafting.

Author information

1
Plastic Surgery Department, Assistance Publique Hôpitaux de Marseilles (AP-HM), Aix-Marseilles University, 13005 Marseilles, France; Culture and Cell Therapy Laboratory, INSERM CBT-1409, Assistance Publique Hôpitaux de Marseilles (AP-HM), Aix-Marseilles University, 13005 Marseilles, France. Electronic address: secretariat.magalon@gmail.com.
2
Internal Medicine Department, Assistance Publique Hôpitaux de Marseilles (AP-HM), Aix-Marseilles University, 13010 Marseilles, France.
3
Culture and Cell Therapy Laboratory, INSERM CBT-1409, Assistance Publique Hôpitaux de Marseilles (AP-HM), Aix-Marseilles University, 13005 Marseilles, France.
4
Culture and Cell Therapy Laboratory, INSERM CBT-1409, Assistance Publique Hôpitaux de Marseilles (AP-HM), Aix-Marseilles University, 13005 Marseilles, France; Vascular Research Center Marseilles, INSERM UMRS-1076, Aix-Marseilles University, 13005 Marseilles, France.
5
Internal Medicine Department, Assistance Publique Hôpitaux de Marseilles (AP-HM), Aix-Marseilles University, 13010 Marseilles, France; Vascular Research Center Marseilles, INSERM UMRS-1076, Aix-Marseilles University, 13005 Marseilles, France.

Abstract

Grafted fat has many qualities of ideal filler; it is autologous, easily available, and naturally integrated into the host tissues. From a lipoaspirate, the adipose-tissue-derived stromal vascular fraction can be isolated, which is an excellent source of stem/stromal cells, endothelial progenitors, and immune cells. Fat grafting is being increasingly applied in autoimmune diseases, and this article focuses on systemic sclerosis, a rare autoimmune disease characterized by skin fibrosis and microvascular damage. The authors' approach of using fat graft in the face and adipose-tissue-derived stromal vascular fraction for hands is presented as innovative and promising therapy for patients with systemic sclerosis.

KEYWORDS:

Adipose tissue; Autologous fat graft; Cell therapy; Fat grafting; Microfat injection; Stromal vascular fraction; Systemic sclerosis

PMID:
26116941
DOI:
10.1016/j.cps.2015.03.009
[Indexed for MEDLINE]

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