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Arch Biochem Biophys. 2016 Jan 1;589:120-30. doi: 10.1016/j.abb.2015.06.013. Epub 2015 Jun 25.

Metabolomics applied to the pancreatic islet.

Author information

1
Sarah W. Stedman Nutrition and Metabolism Center and Duke Molecular Physiology Institute, Departments of Pharmacology and Cancer Biology and Medicine, Duke University, Durham, NC 27701, United States.
2
Sarah W. Stedman Nutrition and Metabolism Center and Duke Molecular Physiology Institute, Departments of Pharmacology and Cancer Biology and Medicine, Duke University, Durham, NC 27701, United States. Electronic address: chris.newgard@dm.duke.edu.

Abstract

Metabolomics, the characterization of the set of small molecules in a biological system, is advancing research in multiple areas of islet biology. Measuring a breadth of metabolites simultaneously provides a broad perspective on metabolic changes as the islets respond dynamically to metabolic fuels, hormones, or environmental stressors. As a result, metabolomics has the potential to provide new mechanistic insights into islet physiology and pathophysiology. Here we summarize advances in our understanding of islet physiology and the etiologies of type-1 and type-2 diabetes gained from metabolomics studies.

KEYWORDS:

Diabetes; Islet; Lipidomics; Metabolic flux; Metabolism; Metabolomics

PMID:
26116790
PMCID:
PMC4863644
DOI:
10.1016/j.abb.2015.06.013
[Indexed for MEDLINE]
Free PMC Article

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