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J Infect Dis. 2015 Jul 15;212 Suppl 1:S42-6. doi: 10.1093/infdis/jiu512.

Polyreactive Antibodies: Function and Quantification.

Author information

1
Experimental Medicine Section, Laboratory of Sensory Biology, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland.

Abstract

Polyreactive antibodies, a major component of the natural antibody repertoire, bind with low affinity to a variety of structurally unrelated antigens. Many of these antibodies are germline or near germline in sequence. Little is known, however, about the function of these antibodies. In the present mini-review we show: (1) that the broad antibacterial activity of the natural antibody repertoire is largely due to polyreactive antibodies, which in the presence of complement lyse bacteria and enhance phagocytosis; (2) that polyreactive antibodies bind to UV- or human immunodeficiency virus-induced apoptotic cells and with complement enhance the phagocytosis of these cells by macrophages; and (3) that dinitrophenol can be used as a surrogate for quantitating the level of polyreactive antibodies in serum. We conclude that polyreactive antibodies protect the host against both foreign invaders and its own damaged/apoptotic cells.

KEYWORDS:

apoptotic cells; bacteria; natural antibody; phagocytosis; polyreactive antibody

PMID:
26116731
PMCID:
PMC4490204
DOI:
10.1093/infdis/jiu512
[Indexed for MEDLINE]
Free PMC Article

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