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J Infect Dis. 2015 Jul 15;212 Suppl 1:S17-25. doi: 10.1093/infdis/jiu656.

Use of a 2-aminothiazole to Treat Chronic Wasting Disease in Transgenic Mice.

Author information

1
Institute for Neurodegenerative Diseases.
2
Institute for Neurodegenerative Diseases Department of Neurology, University of California San Francisco.
3
Department of Pathology.
4
Institute for Neurodegenerative Diseases Department of Pathology.

Abstract

Treatment with the 2-aminothiazole IND24 extended the survival of mice infected with mouse-adapted scrapie but also resulted in the emergence of a drug-resistant prion strain. Here, we determined whether IND24 extended the survival of transgenic mice infected with prions that caused scrapie in sheep or prions that caused chronic wasting disease (CWD; hereafter "CWD prions") in deer, using 2 isolates for each disease. IND24 doubled the incubation times for mice infected with CWD prions but had no effect on the survival of those infected with scrapie prions. Biochemical, neuropathologic, and cell culture analyses were used to characterize prion strain properties following treatment, and results indicated that the CWD prions were not altered by IND24, regardless of survival extension. These results suggest that IND24 may be a viable candidate for treating CWD in infected captive cervid populations and raise questions about why some prion strains develop drug resistance whereas others do not.

KEYWORDS:

chronic wasting disease; prion disease; survival extension; therapeutic; transgenic mice

PMID:
26116725
PMCID:
PMC4551108
DOI:
10.1093/infdis/jiu656
[Indexed for MEDLINE]
Free PMC Article

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