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J Child Neurol. 2016 Mar;31(3):321-7. doi: 10.1177/0883073815592223. Epub 2015 Jun 26.

Case Series: Fractional Anisotropy Profiles of the Cerebellar Peduncles in Adolescents Born Preterm With Ventricular Dilation.

Author information

  • 1Department of Pediatrics, Stanford University School of Medicine, Palo Alto, CA, USA.
  • 2Child Development Center, Tel Aviv Sourasky Medical Center, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.
  • 3The Gonda Brain Research Center, Bar Ilan University, Ramat Gan, Israel Department of English Literature and Linguistics, Bar Ilan University, Ramat Gan, Israel.
  • 4Department of Radiology, Lucile Packard Children's Hospital, Stanford University School of Medicine, Palo Alto, CA, USA.
  • 5Department of Pediatrics, Stanford University School of Medicine, Palo Alto, CA, USA hfeldman@stanford.edu.

Abstract

This case series assesses white matter microstructure of the cerebellar peduncles in 4 adolescents born preterm with enlarged ventricles and reduced white matter volume in the cerebrum but no apparent injury to the cerebellum. Subjects (ages 12-17 years, gestational age 26-32 weeks, birth weight 825-2211 g) were compared to a normative sample of 19 full-term controls (9-17 years, mean gestational age 39 weeks, mean birth weight 3154 g). Tract profiles for each of the cerebellar peduncles were generated by calculating fractional anisotropy at 30 points along the central portion of each tract. One or more case subjects exhibited higher fractional anisotropy beyond the 90th percentile in the inferior, middle, and superior cerebellar peduncles. Findings demonstrate that differences in cerebellar white matter microstructure can be detected in the absence of macrostructural cerebellar abnormalities.

KEYWORDS:

cerebellum; diffusion MRI; preterm; tractography; white matter

PMID:
26116381
PMCID:
PMC4691425
[Available on 2017-03-01]
DOI:
10.1177/0883073815592223
[PubMed - indexed for MEDLINE]
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