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Actas Dermosifiliogr. 2015 Oct;106(8):623-31. doi: 10.1016/j.ad.2015.06.001. Epub 2015 Jun 24.

Spanish-Portuguese consensus statement on use of daylight-mediated photodynamic therapy with methyl aminolevulinate in the treatment of actinic keratosis.

[Article in English, Spanish]

Author information

1
Unidad de Dermatología, Hospital San Jorge, Huesca, España. Electronic address: ygilaberte@salud.aragon.es.
2
Servicio de Dermatología, Hospital Costa del Sol, Marbella, Málaga, España.
3
Servicio de Dermatología, Complejo Hospitalario Universitario, La Coruña, España.
4
Centro de Dermatología Epidermis, Instituto CUF, Oporto y Facultad de Medicina, Universidad de Oporto, Oporto, Portugal.
5
Servicio de Dermatología, Instituto Valencia de Oncología, Valencia, España.
6
Servicio de Dermatología, Hospital Universitario Ramón y Cajal, Madrid, España.
7
Servicio de Dermatología, Estructura Organizativa de Gestión Integrada (EOXI) de Vigo, Clínica Pérez & Gavín dermatólogos, Vigo, España.
8
Servicio de Dermatología, Clínica Universitaria de Navarra, Pamplona, España.
9
Clínica Ruber y Clínica Dermatológica Internacional, Madrid, España.
10
Servicio de Dermatología, Complejo Asistencial Universitario de León, León, España.

Abstract

INTRODUCTION:

Daylight-mediated photodynamic therapy (PDT) is a new type of PDT that is as effective as conventional PDT in grade 1 and 2 actinic keratosis but with fewer adverse effects, resulting in greater efficiency. The climatic conditions in the Iberian Peninsula require an appropriately adapted consensus protocol.

OBJECTIVE:

We describe a protocol for the treatment of grade 1 and 2 actinic keratosis with daylight-mediated PDT and methyl aminolevulinate (MAL) adapted to the epidemiological and clinical characteristics of Spanish and Portuguese patients and the climatic conditions of both countries.

METHODS:

Twelve dermatologists from different parts of Spain and Portugal with experience in the treatment of actinic keratosis with PDT convened to draft a consensus statement for daylight-mediated PDT with MAL in these countries. Based on a literature review and their own clinical experience, the group developed a recommended protocol.

RESULTS:

According to the recommendations adopted, patients with multiple grade 1 and 2 lesions, particularly those at risk of developing cancer, are candidates for this type of therapy. Daylight-mediated PDT can be administered throughout the year, although it is not indicated at temperatures below 10°C or at excessively high temperatures. Likewise, therapy should not be administered when it is raining, snowing, or foggy. The procedure is simple, requiring application of a sunscreen with a protection factor of at least 30 based exclusively on organic filters, appropriate preparation of the lesions, application of MAL without occlusion, and activation in daylight for 2hours.

CONCLUSION:

This consensus statement represents a practical and detailed guideline to achieve maximum effectiveness of daylight-mediated PDT with MAL in Spain and Portugal with minimal adverse effects.

KEYWORDS:

Actinic keratosis; Daylight; Luz de día; Methyl aminolevulinate; Metil-aminolevulinato; Photodynamic therapy; Queratosis actínicas; Terapia fotodinámica

PMID:
26115793
DOI:
10.1016/j.ad.2015.06.001
[Indexed for MEDLINE]

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