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PLoS One. 2015 Jun 26;10(6):e0131451. doi: 10.1371/journal.pone.0131451. eCollection 2015.

New Metrics for Evaluating Viral Respiratory Pathogenesis.

Author information

1
Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States of America.
2
Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States of America; Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States of America.
3
Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States of America.

Abstract

Viral pathogenesis studies in mice have relied on markers of severe systemic disease, rather than clinically relevant measures, to evaluate respiratory virus infection; thus confounding connections to human disease. Here, whole-body plethysmography was used to directly measure changes in pulmonary function during two respiratory viral infections. This methodology closely tracked with traditional pathogenesis metrics, distinguished both virus- and dose-specific responses, and identified long-term respiratory changes following both SARS-CoV and Influenza A Virus infection. Together, the work highlights the utility of examining respiratory function following infection in order to fully understand viral pathogenesis.

PMID:
26115403
PMCID:
PMC4482571
DOI:
10.1371/journal.pone.0131451
[Indexed for MEDLINE]
Free PMC Article

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