Send to

Choose Destination
Crit Rev Food Sci Nutr. 2017 May 24;57(8):1650-1663. doi: 10.1080/10408398.2015.1008980.

Fruit and vegetable consumption and risk of cardiovascular disease: A meta-analysis of prospective cohort studies.

Author information

a School of Public Health, Wuhan University , Wuhan , P. R. China.
b Department of Infection Control , Macheng People's Hospital , Macheng , Hubei , P. R. China.
c Global Health Institute, Wuhan University , Wuhan , P. R. China.


A meta-analysis of prospective cohort studies was conducted to examine the relation between fruit and vegetables (FV) consumption and the risk of cardiovascular disease (CVD). We searched PubMed and EMBASE up to June 2014 for relevant studies. Pooled relative risks (RRs) were calculated and dose-response relationship was assessed. Thirty-eight studies, consisting of 47 independent cohorts, were eligible in this meta-analysis. There were 1,498,909 participants (44,013 CVD events) with a median follow-up of 10.5 years. The pooled RR (95% confidence interval) of CVD for the highest versus lowest category was 0.83 (0.79-0.86) for FV consumption, 0.84 (0.79-0.88) for fruit consumption, and 0.87 (0.83-0.91) for vegetable consumption, respectively. Dose-response analysis showed that those eating 800 g per day of FV consumption had the lowest risk of CVD. Our results indicate that increased FV intake is inversely associated with the risk of CVD. This meta-analysis provides strong support for the current recommendations to consume a high amount of FV to reduce CVD risk.


Fruit; cardiovascular disease; meta-analysis; vegetable

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Taylor & Francis
Loading ...
Support Center