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Curr Opin Immunol. 2015 Aug;35:55-62. doi: 10.1016/j.coi.2015.06.001. Epub 2015 Jun 22.

TB vaccines; promoting rapid and durable protection in the lung.

Author information

1
Statens Serum Institut, Infectious Disease Immunology, 5 Artillerivej, DK-2300 Copenhagen S, Denmark. Electronic address: pa@ssi.dk.
2
Center for Infectious Disease Research (Formerly Seattle Biomedical Research Institute), Seattle, WA 98109, USA; Department of Immunology, University of Washington, Seattle, WA 98109, USA.

Abstract

TB vaccine discovery has focused on IFN-γ both for the selection of antigens and vaccine delivery strategies. Recent breakthroughs in our understanding of the requirements for immunological memory and the expression of immunity to TB in the lung now provide a framework for reconsidering that strategy. We will discuss the status of the TB vaccine field, recent insights into the role of central memory cells and the potential of tissue-resident memory cells in vaccine promoted protection against TB.

PMID:
26113434
PMCID:
PMC4641675
DOI:
10.1016/j.coi.2015.06.001
[Indexed for MEDLINE]
Free PMC Article

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