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Biometrics. 1989 Dec;45(4):1197-211.

Monitoring accumulating data in a clinical trial.

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1
School of Statistics, University of Minnesota, Minneapolis 55455.

Abstract

A clinical trial is monitored for efficacy or safety; the variable of interest is death or a similarly serious event. The probability that one therapy has a greater mortality rate than the other is calculated ad libitum during the trial. Adjustments are made for differing patients' prognoses and for survival times.

PMID:
2611322
[Indexed for MEDLINE]
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