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Biochimie. 2016 Jan;120:56-61. doi: 10.1016/j.biochi.2015.06.010. Epub 2015 Jun 23.

Non-enzymatic cyclic oxygenated metabolites of omega-3 polyunsaturated fatty acid: Bioactive drugs?

Author information

1
UMR CNRS 9214, Inserm U1046, Physiologie et Médecine Expérimentale du cœur et des Muscles - PHYMEDEXP, Université de Montpellier, Montpellier, France.
2
UMR CNRS 9214, Inserm U1046, Physiologie et Médecine Expérimentale du cœur et des Muscles - PHYMEDEXP, Université de Montpellier, Montpellier, France. Electronic address: Jean-Yves.Le-Guennec@Inserm.fr.
3
Institut des Biomolécules Max Mousseron, CNRS UMR 5247, Université de Montpellier, ENSCM, Montpellier, France.
4
The University of Hong Kong, School of Biological Sciences, Hong Kong Special Administrative Region.

Abstract

Non-enzymatic oxygenated metabolites derived from polyunsaturated fatty acids (PUFA) are formed in vivo through free radical reaction under oxidative stress conditions. It has been over twenty-five years since the discovery of cyclic oxygenated metabolites derived from arachidonic acid (20:4 n-6), the isoprostanes, and since then they have become biomarkers of choice for assessing in vivo OS in humans and animals. Chemical synthesis of n-3 PUFA isoprostanoids such as F3-Isoprostanes from eicosapentaenoic acid (20:5 n-3), and F4-Neuroprostanes from docosahexaenoic acid (22:6 n-6) unravelled novel and unexpected biological properties of such omega-3 non-enzymatic cyclic metabolites as highlighted in this review.

KEYWORDS:

Arrhythmia; Isoprostanes; Neuroprostanes; Omega-3 PUFA; Oxidative stress

PMID:
26112019
DOI:
10.1016/j.biochi.2015.06.010
[Indexed for MEDLINE]

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