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Adv Healthc Mater. 2015 Aug 26;4(12):1763-89. doi: 10.1002/adhm.201500201. Epub 2015 Jun 25.

Emerging Trends in Abdominal Wall Reinforcement: Bringing Bio-Functionality to Meshes.

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Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, Donaueschingenstraße 13, A-1200, Vienna, Austria.
Austrian Cluster for Tissue Regeneration, Donaueschingenstrasse 13, A-1200, Vienna, Austria.
University of Applied Sciences Technikum Wien, Department of Biochemical Engineering, Höchstädtplatz 5, 1200, Vienna, Austria.
Department of General Visceral and Oncological Surgery, Wilhelminenspital der Stadt Wien, Montleartstraße 37, A-1171, Vienna, Austria.


Abdominal wall hernia is a recurrent issue world-wide and requires the implantation of over 1 million meshes per year. Because permanent meshes such as polypropylene and polyester are not free of complications after implantation, many mesh modifications and new functionalities have been investigated over the last decade. Indeed, mesh optimization is the focus of intense development and the biomaterials utilized are now envisioned as being bioactive substrates that trigger various physiological processes in order to prevent complications and to promote tissue integration. In this context, it is of paramount interest to review the most relevant bio-functionalities being brought to new meshes and to open new avenues for the innovative development of the next generation of meshes with enhanced properties for functional abdominal wall hernia repair.


cells; coating; drug delivery systems; hernias; meshes

[Indexed for MEDLINE]

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