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PLoS One. 2015 Jun 25;10(6):e0131114. doi: 10.1371/journal.pone.0131114. eCollection 2015.

Susceptibility-weighted imaging provides insight into white matter damage in amyotrophic lateral sclerosis.

Author information

1
Hans-Berger Department of Neurology, Jena University Hospital, Erlanger Allee 101, 07747, Jena, Germany.
2
Department of Radiology, HELIOS Kreiskrankenhaus Gotha, 99867, Gotha, Germany.
3
Department of Neurology, University of Göttingen, 37075, Göttingen, Germany.
4
Buffalo Neuroimaging Analysis Center, Department of Neurology, School of Medicine and Biomedical Sciences, State University of New York at Buffalo, New York, United States of America; MRI Clinical and Translational Research Center, School of Medicine and Biomedical Sciences, State University of New York at Buffalo, New York, United States of America.
5
Medical Physics Group, Institute of Diagnostic and Interventional Radiology, Jena University Hospital, Philosophenweg 3, 07743, Jena, Germany.
6
Department of Neuroradiology, Jena University Hospital, Erlanger Allee 101, 07747, Jena, Germany.

Abstract

BACKGROUND:

Amyotrophic lateral sclerosis (ALS) is a fatal, progressive neurodegenerative disorder, characterised by widespread white matter damage. There is growing evidence that disturbances in iron metabolism contribute to white matter alterations.

MATERIALS & METHODS:

We analysed the data of susceptibility-weighted imaging (SWI) of white matter in a cohort of 27 patients with ALS and 30 healthy age-matched controls.

RESULTS:

Signal alterations were found on SWI in the corpus callosum; along the corticospinal tract (subcortical motor cortex, posterior limb of the internal capsule and brainstem levels) and in the subgyral regions of frontal, parietal, temporal, occipital and limbic lobes. Alterations of white matter in the corpus callosum correlated with disease severity as assessed by the revised ALS functional rating scale.

CONCLUSION:

SWI is capable of indicating iron and myelin disturbances in white matter of ALS patients. The SWI patterns observed in this study suggest that widespread alterations due to iron disturbances occur in patients with ALS and correlate with disease severity.

PMID:
26110427
PMCID:
PMC4481412
DOI:
10.1371/journal.pone.0131114
[Indexed for MEDLINE]
Free PMC Article

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