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Behav Pharmacol. 2015 Dec;26(8 Spec No):733-40. doi: 10.1097/FBP.0000000000000152.

Hyperactivity and lack of social discrimination in the adolescent Fmr1 knockout mouse.

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aDepartment of Clinical Medicine, Center of Functionally Integrative Neuroscience/MINDLab bDepartment of Biomedicine, Aarhus University cDepartment of Nuclear Medicine & PET centre, Aarhus University Hospital, Aarhus C dLaboratory of Neuropsychiatry, Department of Psychiatry, Copenhagen University Hospital, Copenhagen, Denmark.


The aims of this study were to investigate behaviour relevant to human autism spectrum disorder (ASD) and the fragile X syndrome in adolescent Fmr1 knockout (KO) mice and to evaluate the tissue levels of striatal monoamines. Fmr1 KO mice were evaluated in the open field, marble burying and three-chamber test for the presence of hyperactivity, anxiety, repetitive behaviour, sociability and observation of social novelty compared with wild-type (WT) mice. The Fmr1 KO mice expressed anxiety and hyperactivity in the open field compared with WT mice. This increased level of hyperactivity was confirmed in the three-chamber test. Fmr1 KO mice spent more time with stranger mice compared with the WT. However, after a correction for hyperactivity, their apparent increase in sociability became identical to that of the WT. Furthermore, the Fmr1 KO mice could not differentiate between a familiar or a novel mouse. Monoamines were measured by HPLC: Fmr1 KO mice showed an increase in the striatal dopamine level. We conclude that the fragile X syndrome model seems to be useful for understanding certain aspects of ASD and may have translational interest for studies of social behaviour when hyperactivity coexists in ASD patients.

[Indexed for MEDLINE]

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