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Open Forum Infect Dis. 2015 Feb 2;2(2):ofv013. doi: 10.1093/ofid/ofv013. eCollection 2015 Apr.

Only a Touch of the Flu? The Simultaneous Manifestation of Acute Necrotizing Encephalopathy in Two Consanguineous Patients.

Author information

1
Department of Infectious Diseases , County Hospital Baden.
2
University Children's Hospital of Both Basel Counties.
3
Departments of Neuroradiology.
4
Neurology.
5
Infectious Diseases and Hospital Epidemiology , University Hospital Basel , Switzerland.

Abstract

This case report describes the simultaneous manifestation of acute necrotizing encephalopathy in 2 consanguineous patients after infection with influenza B based on the autosomal dominant missense mutation of the RANBP2-gene. Differential diagnosis of acute encephalopathy, clinical and radiological clues, and treatment strategies are outlined.

KEYWORDS:

ANE; RANBP2-gene; encephalopathy; genetic; influenza

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