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Neural Regen Res. 2015 May;10(5):766-71. doi: 10.4103/1673-5374.157243.

Lateral intracerebroventricular injection of Apelin-13 inhibits apoptosis after cerebral ischemia/reperfusion injury.

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Xinxiang Medical University, Xinxiang, Henan Province, China.
Neurobiology Institute, Jining Medical University, Jining, Shandong Province, China.
Taishan Medical University, Taian, Shandong Province, China.


Apelin-13 inhibits neuronal apoptosis caused by hydrogen peroxide, yet apoptosis following cerebral ischemia-reperfusion injury has rarely been studied. In this study, Apelin-13 (0.1 μg/g) was injected into the lateral ventricle of middle cerebral artery occlusion model rats. TTC, TUNEL, and immunohistochemical staining showed that compared with the cerebral ischemia/reperfusion group, infarct volume and apoptotic cell number at the ischemic penumbra region were decreased in the Apelin-13 treatment group. Additionally, Apelin-13 treatment increased Bcl-2 immunoreactivity and decreased caspase-3 immunoreactivity. Our findings suggest that Apelin-13 is neuroprotective against cerebral ischemia/reperfusion injury through inhibition of neuronal apoptosis.


Apelin-13; Bcl-2; NSFC grants; brain injury; caspase-3; cerebral ischemia/reperfusion injury; lateral intracerebroventricular injection; nerve apoptosis; nerve regeneration; neural regeneration; neuroprotection

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