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G3 (Bethesda). 2015 Jun 24;5(8):1737-49. doi: 10.1534/g3.115.018937.

Gene Model Annotations for Drosophila melanogaster: The Rule-Benders.

Author information

1
Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, crosby@morgan.harvard.edu.
2
Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138.

Abstract

In the context of the FlyBase annotated gene models in Drosophila melanogaster, we describe the many exceptional cases we have curated from the literature or identified in the course of FlyBase analysis. These range from atypical but common examples such as dicistronic and polycistronic transcripts, noncanonical splices, trans-spliced transcripts, noncanonical translation starts, and stop-codon readthroughs, to single exceptional cases such as ribosomal frameshifting and HAC1-type intron processing. In FlyBase, exceptional genes and transcripts are flagged with Sequence Ontology terms and/or standardized comments. Because some of the rule-benders create problems for handlers of high-throughput data, we discuss plans for flagging these cases in bulk data downloads.

KEYWORDS:

bicistronic; multiphasic exon; non-AUG translation start; shared promoter; stop-codon suppression

PMID:
26109356
PMCID:
PMC4528330
DOI:
10.1534/g3.115.018937
[Indexed for MEDLINE]
Free PMC Article

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