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Vet Comp Oncol. 2016 Aug;14 Suppl 1:136-46. doi: 10.1111/vco.12158. Epub 2015 Jun 25.

Treatment of feline intermediate- to high-grade lymphoma with a modified university of Wisconsin-Madison protocol: 119 cases (2004-2012).

Author information

1
Veterinary Medical Teaching Hospital, University of California-Davis, Davis, CA, USA.
2
Oncology Service, Upstate Veterinary Specialists, Greenville, SC, USA.
3
Department of Surgical and Radiological Sciences, University of California-Davis, Davis, CA, USA.
4
Oncology Service, Blue Pearl Veterinary Partners, Louisville, KY, USA.
5
Department of Medical Sciences, Univeristy of Wisconsin-Madison, Madison, WI, USA.
6
Department of Pathology, Microbiology and Immunology, University of California-Davis, CA, USA.
7
Department of Clinical Sciences, Auburn University, Auburn, AL, USA.
8
Department of Veterinary Clinical Medicine, University of Illinois, Urbana, IL, USA.
9
Department of Veterinary Clinical Sciences, Washington State University, Pullman, WA, USA.
10
Oncology Service, Seattle Veterinary Specialists, Seattle, WA, USA.

Abstract

CHOP-based (cyclophosphamide, doxorubicin, vinca alkaloid, prednisolone) chemotherapy protocols are often recommended for treatment of feline lymphoma. While maintenance-free CHOP-based protocols have been published and readily used in dogs, there is limited literature regarding similar maintenance-free protocols in cats. The purpose of this study was to describe the outcome of cats with intermediate- to high-grade lymphoma that were prescribed a modified 25-week University of Wisconsin-Madison (UW-25) chemotherapy protocol. A secondary objective was examination of potential prognostic factors. One hundred and nineteen cats from five institutions treated with a UW-25-based protocol were included. The Kaplan-Meier median progression-free interval (PFI) and survival time (MST) were 56 and 97 (range 2-2019) days, respectively. Cats assessed as having a complete response (CR) to therapy had significantly longer PFI and MST than those with partial or no response (PFI 205 versus 54 versus 21 days, respectively, P < 0.0001 and MST 318 versus 85 versus 27 days, respectively, P < 0.0001).

KEYWORDS:

CHOP; cat; feline; lymphoma; maintenance-free chemotherapy; survival

PMID:
26109275
PMCID:
PMC5012421
DOI:
10.1111/vco.12158
[Indexed for MEDLINE]
Free PMC Article

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