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Sci Rep. 2015 Jun 25;5:11601. doi: 10.1038/srep11601.

A single-dose of oral nattokinase potentiates thrombolysis and anti-coagulation profiles.

Author information

1
Department of Sport and Health Science, Ritsumeikan University, Kusatsu, Shiga, Japan.
2
Department of Economics, Tokuyama University, Shunan, Yamaguchi, Japan.
3
Department of Clinical Chemistry, Kobe Pharmaceutical University, Kobe, Hyogo, Japan.
4
Department of Neurology, University of Cincinnati, Cincinnati, Ohio, USA.

Abstract

Our aim was to determine the quantitative effects of a single-dose of Nattokinase (NK) administration on coagulation/fibrinolysis parameters comprehensively in healthy male subjects. A double-blind, placebo-controlled cross-over NK intervention study was carried out in 12 healthy young males. Following the baseline blood draw, each subject was randomized to receive either a single-dose of 2,000 FU NK (NSK-SD, Japan Bio Science Laboratory Co., Ltd) or placebo with subsequent cross-over of the groups. Subjects donated blood samples at 2, 4, 6 and 8 hours following administration for analysis of coagulation/fibrinolysis parameters. As a result, D-dimer concentrations at 6, and 8 hours, and blood fibrin/fibrinogen degradation products at 4 hours after NK administration elevated significantly (p < 0.05, respectively). Factor VIII activity declined at 4 and 6 hours (p < 0.05, respectively), blood antithrombin concentration was higher at 2 and 4 hours (p < 0.05, respectively), and the activated partial thromboplastin time prolonged significantly at 2 and 4 hours following NK administration (p < 0.05 and p < 0.01, respectively). All the changes, however, were within the normal range. In conclusion, thus, a single-dose of NK administration appears enhancing fibrinolysis and anti-coagulation via several different pathways simultaneously.

PMID:
26109079
PMCID:
PMC4479826
DOI:
10.1038/srep11601
[Indexed for MEDLINE]
Free PMC Article

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