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Pharm Res. 2015 Nov;32(11):3577-83. doi: 10.1007/s11095-015-1729-8. Epub 2015 Jun 25.

Internalization, Trafficking, Intracellular Processing and Actions of Antibody-Drug Conjugates.

Author information

1
Scientific Development Manager, Discovery Biology, GenScript USA Inc., 860 Centennial Ave., Piscataway, New Jersey, 08854, USA. ben.xu@genscript.com.

Abstract

PURPOSE:

This review discusses the molecular mechanism involved in the targeting and delivery of antibody-drug conjugates (ADCs), the new class of biopharmaceuticals mainly designed for targeted cancer therapy.

METHODS:

this review goes over major progress in preclinical and clinical studies of ADCs, in the past 5 years.

RESULTS:

The pharmacokinetics and pharmacodynamics of ADCs involve multiple mechanisms, including internalization of ADCs by target cells, intracellular trafficking, release of conjugated drugs, and payload.

CONCLUSION:

These mechanisms actually jointly determine the efficacy of ADCs. Therefore, the optimization of ADCs should take them as necessary rationales.

KEYWORDS:

Antibody drug conjugate; Internalization; Linker; Recycling; Trafficking

PMID:
26108878
DOI:
10.1007/s11095-015-1729-8
[Indexed for MEDLINE]

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