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J Med Toxicol. 2015 Sep;11(3):342-54. doi: 10.1007/s13181-015-0488-6.

A Review of the Toxicologic Implications of Obesity.

Author information

1
University of Colorado, Anschutz Medical Campus, 12401 East 17th Avenue, Rm 759, Aurora, CO, 80045, USA, matthew.zuckerman@ucdenver.edu.

Abstract

The increasing prevalence of obesity in developed nations has far-reaching implications for medical toxicology. The management of obese patients is complicated by comorbid illnesses, changes in cardiovascular and respiratory physiology, alterations in pharmacokinetics, and a lack of studies to identify appropriate dosing for current therapeutics and antidotes. In this review article, we examine obesity-associated physiologic and pharmacokinetic changes that may increase the vulnerability of obese patients to overdose. Further research is needed to characterize the relationship between drug toxicity and obesity.

PMID:
26108709
PMCID:
PMC4547963
DOI:
10.1007/s13181-015-0488-6
[Indexed for MEDLINE]
Free PMC Article

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