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Biochem Biophys Res Commun. 1989 Dec 29;165(3):944-1003.

Liver mitochondrial respiratory functions decline with age.

Author information

1
Department of Biochemistry, National Yang-Ming Medical College, Taipei, Taiwan, Republic of China.

Abstract

Human liver mitochondrial respiration rates in Chinese populations of various ages were assayed with an oxygraph. In this study, State 3 and State 4 respiration rates, respiratory control ratio (RCR), and ADP/O ratio were measured for 35 Chinese subjects of 31 to 76 years old. We found a significant negative correlation between age and respiratory control and ADP/O ratios tested. Moreover, the respiratory control and ADP/O ratios decreased with the increase of age. These findings suggest that a substantial fall in mitochondrial oxidative capacity in ageing liver may be an important contributor to the ageing process.

PMID:
2610701
[Indexed for MEDLINE]

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