Format

Send to

Choose Destination
Exp Mol Pathol. 2015 Aug;99(1):151-4. doi: 10.1016/j.yexmp.2015.06.011. Epub 2015 Jun 21.

Phenomenon of individual difference in human monocyte activation.

Author information

1
Laboratory of Angiopathology, Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow 125315, Russia; Department of Biophysics, Faculty of Biology, Moscow State University, Moscow 119991, Russia; Institute for Atherosclerosis Research, Skolkovo Innovative Center, Moscow 143025, Russia.
2
Laboratory of Angiopathology, Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow 125315, Russia; Institute for Atherosclerosis Research, Skolkovo Innovative Center, Moscow 143025, Russia.
3
Katholieke Universiteit Leuven, Department of Growth and Regeneration, Campus Gasthuisberg O&N1 Herestraat 49-BUS 817, 3000 Leuven, Belgium. Electronic address: kate.ivanov@gmail.com.
4
Vavilov Institute of General Genetics, Russian Academy of Sciences, Moscow 119991, Russia.

Abstract

Macrophages play an important role in the pathogenesis of atherosclerosis, including the early pre-clinical stages of the disease development. We have explored the possibility that the disease onset could be associated with altered monocyte/macrophage response to activating pro- and anti-inflammatory stimuli. We evaluated the susceptibility of circulating monocytes from healthy individuals and patients with asymptomatic carotid atherosclerosis to M1 and M2 activation. The obtained data indicated the existence of a remarkable individual difference in susceptibility to activation among monocytes isolated from the blood of different subjects, regardless of the presence or absence of atherosclerosis. The identified differences in susceptibility to activation between monocytes may explain the individual peculiarities of the immune response in different subjects.

KEYWORDS:

Activation; Cholesterol; Cytokine; Individual profile; Monocyte

PMID:
26107006
DOI:
10.1016/j.yexmp.2015.06.011
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center