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Tierarztl Prax Ausg K Kleintiere Heimtiere. 2015;43(5):331-6. doi: 10.15654/TPK-141112. Epub 2015 Jun 24.

[Dermatomyositis in a family of Working Kelpies].

[Article in English, German]

Author information

1
Dr. Anja Röthig, Klinik für Kleintiere, Justus-Liebig-Universität Gießen, Frankfurter Straße 126, 35392 Gießen, E-Mail: anja.roethig@vetmed.uni-giessen.de.

Abstract

Eight members of a family of Working Kelpies were presented with signs compatible with dermatomyositis. Alopecia, crusts, ulcerations of the skin, depigmentation of nasal planum and lips, onychodystrophy and atrophy of the masticatory muscles were present with varying degree. Histopathology of the skin, but not from muscles was performed in three dogs and confirmed the clinical diagnosis. Different immunomodulating drugs (steroids, cyclosporine, mycophenolate mofetil, pentoxifylline, doxycyline/niacinamid, omega-3 fatty acids and vitamin E) were used with variable success. Dermatomyositis is an immune-mediated disease and a genetic predisposition is known in humans and certain canine breeds, mainly Shetland Sheepdogs and Collies, but also for the Beauceron. The responsible genes have not been identified so far. It is assumed that the Working Kelpie derives from the Collie which could explain a hereditary predisposition in the Kelpie.

KEYWORDS:

Ischemic dermatopathy; canine; vasculitis

PMID:
26105578
DOI:
10.15654/TPK-141112
[Indexed for MEDLINE]

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