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Nat Rev Cancer. 2015 Jul;15(7):397-408. doi: 10.1038/nrc3960.

Forging a signature of in vivo senescence.

Author information

1
Department of Medicine and Genetics and The Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599-7295, USA.
2
Department of Tumor Cell Biology and The Howard Hughes Medical Institute, St. Jude Children's Research Hospital, Memphis, Tennessee 38105-2794, USA.

Erratum in

  • Nat Rev Cancer. 2015 Aug;15(8):509.

Abstract

'Cellular senescence', a term originally defining the characteristics of cultured cells that exceed their replicative limit, has been broadened to describe durable states of proliferative arrest induced by disparate stress factors. Proposed relationships between cellular senescence, tumour suppression, loss of tissue regenerative capacity and ageing suffer from lack of uniform definition and consistently applied criteria. Here, we highlight caveats in interpreting the importance of suboptimal senescence-associated biomarkers, expressed either alone or in combination. We advocate that more-specific descriptors be substituted for the now broadly applied umbrella term 'senescence' in defining the suite of diverse physiological responses to cellular stress.

PMID:
26105537
DOI:
10.1038/nrc3960
[Indexed for MEDLINE]
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