Format

Send to

Choose Destination
Eur Radiol. 2016 Mar;26(3):807-15. doi: 10.1007/s00330-015-3879-9. Epub 2015 Jun 25.

Increasing signal intensity within the dentate nucleus and globus pallidus on unenhanced T1W magnetic resonance images in patients with relapsing-remitting multiple sclerosis: correlation with cumulative dose of a macrocyclic gadolinium-based contrast agent, gadobutrol.

Author information

1
Faculty of Medicine, University of Nis, Nis, Serbia, Bul. Dr. Z. Djindjica 82. drstojanov@gmail.com.
2
Center for Radiology, Clinical Center Nis, Nis, Serbia, Bul. Dr. Z. Djindjica 48. drstojanov@gmail.com.
3
Center for Radiology, Clinical Center Nis, Nis, Serbia, Bul. Dr. Z. Djindjica 48. aaracki@gmail.com.
4
Faculty of Medicine, University of Nis, Nis, Serbia, Bul. Dr. Z. Djindjica 82. boban2@eunet.rs.
5
Clinic for Neurology, Clinical Center Nis, Nis, Serbia, Bul. Dr. Z. Djindjica 48. boban2@eunet.rs.
6
Faculty of Medicine, University of Nis, Nis, Serbia, Bul. Dr. Z. Djindjica 82. stojanovd@ptt.rs.
7
Faculty of Medicine, University of Nis, Nis, Serbia, Bul. Dr. Z. Djindjica 82. srljub@gmail.com.
8
Clinic for Neurology, Clinical Center Nis, Nis, Serbia, Bul. Dr. Z. Djindjica 48. srljub@gmail.com.

Abstract

OBJECTIVE:

To evaluate correlation between cumulative dose of gadobutrol and signal intensity (SI) within dentate nucleus and globus pallidus on unenhanced T1-weighted images in patients with relapsing-remitting multiple sclerosis (RRMS).

METHODS:

Dentate nucleus-to-pons and globus pallidus-to-thalamus SI ratios, and renal and liver functions, were evaluated after multiple intravenous administrations of 0.1 mmol/kg gadobutrol at 27, 96-98, and 168 weeks. We compared SI ratios based on the number of administrations, total amount of gadobutrol administered, and time between injections.

RESULTS:

Globus pallidus-to-thalamus (p = 0.025) and dentate nucleus-to-pons (p < 0.001) SI ratios increased after multiple gadobutrol administrations, correlated with the number of administrations (ρ = 0.263, p = 0.046, respectively) and depended on the length of administration (p = 0.017, p = 0.037, respectively). Patients receiving gadobutrol at 27 weeks showed the greatest increase in both SI ratios (p = 0.006; p = 0.014, respectively, versus 96-98 weeks). GGT increased at the end of the study (p = 0.004).

CONCLUSION:

In patients with RRMS, SI within the dentate nucleus and globus pallidus increased on unenhanced T1-weighted images after multiple gadobutrol injections. Administration of the same total amount of gadobutrol over a shorter period caused greater SI increase.

KEY POINTS:

Gadolinium deposition may occur within the human brain after multiple gadolinium contrast administrations. Increasing T1W signal intensity occurs within the dentate nucleus and globus pallidus. Increasing signal intensity may be a consequence of multiple administrations of gadobutrol. Administration of gadobutrol over a shorter period causes greater signal intensity increase.

KEYWORDS:

Contrast media; Dentate nucleus; Gadolinium deposition; Globus pallidus; Magnetic resonance imaging

PMID:
26105022
DOI:
10.1007/s00330-015-3879-9
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Springer
Loading ...
Support Center