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J Cereb Blood Flow Metab. 2015 Nov;35(11):1852-61. doi: 10.1038/jcbfm.2015.143. Epub 2015 Jun 24.

The effects of perturbed cerebral blood flow and cerebrovascular reactivity on structural MRI and behavioral readouts in mild traumatic brain injury.

Author information

1
Research Imaging Institute, University of Texas Health Science Center, San Antonio, Texas, USA.
2
Departments of Cellular and Structure Biology, University of Texas Health Science Center, San Antonio, Texas, USA.
3
Department of Neurology, University of Texas Health Science Center, Houston, Texas, USA.
4
Department of Opthalmology, University of Texas Health Science Center, San Antonio, Texas, USA.
5
South Texas Veterans Health Care System, San Antonio, Texas, USA.

Abstract

This study investigated the effects of perturbed cerebral blood flow (CBF) and cerebrovascular reactivity (CR) on relaxation time constant (T2), apparent diffusion coefficient (ADC), fractional anisotropy (FA), and behavioral scores at 1 and 3 hours, 2, 7, and 14 days after traumatic brain injury (TBI) in rats. Open-skull TBI was induced over the left primary forelimb somatosensory cortex (N=8 and 3 sham). We found the abnormal areas of CBF and CR on days 0 and 2 were larger than those of the T2, ADC, and FA abnormalities. In the impact core, CBF was reduced on day 0, increased to 2.5 times of normal on day 2, and returned toward normal by day 14, whereas in the tissue surrounding the impact, hypoperfusion was observed on days 0 and 2. CR in the impact core was negative, most severe on day 2 but gradually returned toward normal. T2, ADC, and FA abnormalities in the impact core were detected on day 0, peaked on day 2, and pseudonormalized by day 14. Lesion volumes peaked on day 2 and were temporally correlated with forelimb asymmetry and foot-fault scores. This study quantified the effects of perturbed CBF and CR on structural magnetic resonance imaging and behavioral readouts.

PMID:
26104285
PMCID:
PMC4635242
DOI:
10.1038/jcbfm.2015.143
[Indexed for MEDLINE]
Free PMC Article

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