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Nat Commun. 2015 Jun 24;6:7506. doi: 10.1038/ncomms8506.

Exosomes released by keratinocytes modulate melanocyte pigmentation.

Author information

1
1] Institut Curie, PSL Research University, UMR144, CNRS, F-75248 Paris, France [2] Structure and Membrane Compartments, Centre National de la Recherche Scientifique, UMR144, Paris F-75248, France [3] Cell and Tissue Imaging Facility, Infrastructures en Biologie Santé et Agronomie (IBiSA), Paris F-75248, France.
2
1] Institut Curie, PSL Research University, UMR144, CNRS, F-75248 Paris, France [2] Structure and Membrane Compartments, Centre National de la Recherche Scientifique, UMR144, Paris F-75248, France.
3
Institut Curie, Centre de Recherche, Laboratoire de Spectrométrie de Masse Protéomique, Paris F-75248, France.
4
Laboratoires Clarins-31 chaussée Jules César, Pontoise 95300, France.

Abstract

Cells secrete extracellular vesicles (EVs), exosomes and microvesicles, which transfer proteins, lipids and RNAs to regulate recipient cell functions. Skin pigmentation relies on a tight dialogue between keratinocytes and melanocytes in the epidermis. Here we report that exosomes secreted by keratinocytes enhance melanin synthesis by increasing both the expression and activity of melanosomal proteins. Furthermore, we show that the function of keratinocyte-derived exosomes is phototype-dependent and is modulated by ultraviolet B. In sum, this study uncovers an important physiological function for exosomes in human pigmentation and opens new avenues in our understanding of how pigmentation is regulated by intercellular communication in both healthy and diseased states.

PMID:
26103923
PMCID:
PMC4491833
DOI:
10.1038/ncomms8506
[Indexed for MEDLINE]
Free PMC Article

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