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Br J Cancer. 2015 Jul 28;113(3):562-8. doi: 10.1038/bjc.2015.224. Epub 2015 Jun 23.

Reproductive and hormonal factors and mortality among women with colorectal cancer in the NIH-AARP Diet and Health Study.

Author information

1
Division of Cancer Epidemiology and Genetics, National Cancer Institute, 9609 Medical Center Drive, Bethesda, MD 20892, USA.
2
Division of Public Health Sciences, Washington University School of Medicine in St. Louis, 660 S. Euclid Avenue, Campus Box 8100, St Louis, MO 63110, USA.
3
Division of Oncology/Hematology, Winthrop University Hospital, 259 First Street, Mineola, NY 11501, USA.
4
Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, 2 Norfolk Place, London W2 1PG, UK.

Abstract

BACKGROUND:

Although use of menopausal hormone therapy (MHT) and some reproductive factors have been associated with colorectal cancer (CRC) risk, relations between these factors and survival after CRC diagnosis are unclear.

METHODS:

Among 2053 post-menopausal women diagnosed with incident CRC in the NIH-AARP Diet and Health Study, we calculated hazard ratios (HRs) and 95% confidence intervals (CIs) using multivariable Cox proportional hazards regression to test associations between oral contraceptive (OC) use, menarche age, age at first birth, parity, menopausal age, and MHT use with all-cause and CRC-specific mortality.

RESULTS:

There were 759 deaths (332 CRC-related deaths) over a median follow-up of 7.7 years. We observed no statistically significant associations between OC use, menarche age, age at first birth, parity, menopausal age, and mortality. Compared with never MHT use, former use was not associated with mortality, but we found an inverse association among baseline current users, for both all-cause (HR=0.79, 95% CI 0.66-0.94) and CRC mortality (0.76, 0.59-0.99).

CONCLUSION:

Future studies should further focus on the mechanisms by which exogenous oestrogen exposure might affect tumour progression and CRC survival.

PMID:
26103572
PMCID:
PMC4522633
DOI:
10.1038/bjc.2015.224
[Indexed for MEDLINE]
Free PMC Article

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