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Womens Health (Lond). 2015 Jun;11(3):295-307. doi: 10.2217/whe.15.7.

Should all women be screened for thyroid dysfunction in pregnancy?

Author information

1
Thyroid Research Group, Institute of Molecular & Experimental Medicine, Cardiff University School of Medicine, Cardiff, UK.

Abstract

The subject of universal thyroid screening in pregnancy generates impassioned debate. Thyroid dysfunction is common, has significant adverse implications for fetal and maternal well-being, is readily detectable and can be effectively and inexpensively treated. Furthermore, the currently recommended case-finding strategy does not identify a substantially proportion of women with thyroid dysfunction thus favoring universal screening. On the other hand subclinical thyroid dysfunction forms the bulk of gestational thyroid disorders and the paucity of high-level evidence to support correction of these asymptomatic biochemical abnormalities weighs against universal screening. This review critically appraises the literature, examines the pros and cons of universal thyroid screening in pregnancy, highlighting the now strong case for implementing universal screening and explores strategies for its implementation.

KEYWORDS:

child neurodevelopment; hyperthyroidism; hypothyroidism; isolated hypothyroxinemia; levothyroxine; pregnancy; screening; subclinical hypothyroidism

PMID:
26102469
DOI:
10.2217/whe.15.7
[Indexed for MEDLINE]

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