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Nat Commun. 2015 Jun 23;6:7489. doi: 10.1038/ncomms8489.

Ganoderma lucidum reduces obesity in mice by modulating the composition of the gut microbiota.

Author information

1
1] Center for Molecular and Clinical Immunology, Chang Gung University, Gueishan, Taoyuan 33302, Taiwan, ROC [2] Department of Medical Biotechnology and Laboratory Science, College of Medicine, Chang Gung University, Gueishan, Taoyuan 33302, Taiwan, ROC [3] Department of Laboratory Medicine, Chang Gung Memorial Hospital, Linkou, Gueishan, Taoyuan 33305, Taiwan, ROC [4] Department of Microbiology and Immunology, Chang Gung University, Gueishan, Taoyuan 33302, Taiwan, ROC [5] Research Center of Bacterial Pathogenesis, Chang Gung University, Gueishan, Taoyuan 33302, Taiwan, ROC.
2
1] Center for Molecular and Clinical Immunology, Chang Gung University, Gueishan, Taoyuan 33302, Taiwan, ROC [2] Department of Medical Biotechnology and Laboratory Science, College of Medicine, Chang Gung University, Gueishan, Taoyuan 33302, Taiwan, ROC [3] Department of Laboratory Medicine, Chang Gung Memorial Hospital, Linkou, Gueishan, Taoyuan 33305, Taiwan, ROC [4] Research Center of Bacterial Pathogenesis, Chang Gung University, Gueishan, Taoyuan 33302, Taiwan, ROC.
3
Department of Respiratory Therapy, Fu Jen Catholic University, Xinzhuang, New Taipei City 24205, Taiwan, ROC.
4
Center for Molecular and Clinical Immunology, Chang Gung University, Gueishan, Taoyuan 33302, Taiwan, ROC.
5
1] Chang Gung Biotechnology Corporation, Taipei 10508, Taiwan, ROC [2] Biochemical Engineering Research Center, Ming Chi University of Technology, Taishan, New Taipei City 24301, Taiwan, ROC.
6
1] Center for Molecular and Clinical Immunology, Chang Gung University, Gueishan, Taoyuan 33302, Taiwan, ROC [2] Department of Biomedical Sciences, University of the Pacific, Arthur Dugoni School of Dentistry, San Francisco, California 94103, USA.
7
Research Center of Bacterial Pathogenesis, Chang Gung University, Gueishan, Taoyuan 33302, Taiwan, ROC.
8
1] Department of Medical Biotechnology and Laboratory Science, College of Medicine, Chang Gung University, Gueishan, Taoyuan 33302, Taiwan, ROC [2] Department of Laboratory Medicine, Chang Gung Memorial Hospital, Linkou, Gueishan, Taoyuan 33305, Taiwan, ROC.
9
Department of Microbiology and Immunology, Chang Gung University, Gueishan, Taoyuan 33302, Taiwan, ROC.
10
1] Center for Molecular and Clinical Immunology, Chang Gung University, Gueishan, Taoyuan 33302, Taiwan, ROC [2] Chang Gung Biotechnology Corporation, Taipei 10508, Taiwan, ROC [3] Biochemical Engineering Research Center, Ming Chi University of Technology, Taishan, New Taipei City 24301, Taiwan, ROC [4] Laboratory of Cellular Physiology and Immunology, Rockefeller University, New York, New York 10021, USA.

Abstract

Obesity is associated with low-grade chronic inflammation and intestinal dysbiosis. Ganoderma lucidum is a medicinal mushroom used in traditional Chinese medicine with putative anti-diabetic effects. Here, we show that a water extract of Ganoderma lucidum mycelium (WEGL) reduces body weight, inflammation and insulin resistance in mice fed a high-fat diet (HFD). Our data indicate that WEGL not only reverses HFD-induced gut dysbiosis-as indicated by the decreased Firmicutes-to-Bacteroidetes ratios and endotoxin-bearing Proteobacteria levels-but also maintains intestinal barrier integrity and reduces metabolic endotoxemia. The anti-obesity and microbiota-modulating effects are transmissible via horizontal faeces transfer from WEGL-treated mice to HFD-fed mice. We further show that high molecular weight polysaccharides (>300 kDa) isolated from the WEGL extract produce similar anti-obesity and microbiota-modulating effects. Our results indicate that G. lucidum and its high molecular weight polysaccharides may be used as prebiotic agents to prevent gut dysbiosis and obesity-related metabolic disorders in obese individuals.

PMID:
26102296
PMCID:
PMC4557287
DOI:
10.1038/ncomms8489
[Indexed for MEDLINE]
Free PMC Article

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