Format

Send to

Choose Destination
DNA Cell Biol. 2015 Sep;34(9):557-60. doi: 10.1089/dna.2015.2957. Epub 2015 Jun 23.

FGDF motif regulation of stress granule formation.

Author information

1
Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet , Stockholm, Sweden .

Abstract

RNA stress granules (SGs) represent a cell-intrinsic antiviral defense mechanism. The assembly of SGs in response to viral infection is coordinated by the cellular protein G3BP, which is targeted by many viruses to block SG formation. We recently showed that proteins containing the short linear motif Phe-Gly-Asp-Phe (FGDF), bind G3BP in a hydrophobic groove on the surface of the nuclear transport factor-2-like domain. Binding in this manner blocks the ability of G3BP to form SGs and allows efficient replication of viruses carrying this motif.

PMID:
26101899
DOI:
10.1089/dna.2015.2957
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Atypon
Loading ...
Support Center