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Adv Healthc Mater. 2015 Aug 26;4(12):1813-8. doi: 10.1002/adhm.201500307. Epub 2015 Jun 23.

Selenite-Releasing Bone Mineral Nanoparticles Retard Bone Tumor Growth and Improve Healthy Tissue Functions In Vivo.

Wang Y1,2, Hao H1,2, Liu H1,2, Wang Y1,2, Li Y3, Yang G1,2, Ma J1,2, Mao C4, Zhang S1,2.

Author information

1
Advanced Biomaterials and Tissue Engineering Center, Huazhong University of Science and Technology, Wuhan, 430074, China.
2
Department of Biomedical Engineering, Huazhong University of Science and Technology, Wuhan, 430074, China.
3
Department of Oncology, Zhongnan Hospital of Wuhan University, Hubei Key Laboratory of Tumor Biological Behaviors and Hubei Cancer Clinical Study Center, Wuhan, 430074, China.
4
Department of Chemistry and Biochemistry, Stephenson Life Sciences Research Center, University of Oklahoma, Norman, Oklahoma, 73019, USA.

Abstract

Selenite-doped bone mineral nanoparticles can retard the growth of osteosarcoma in a nude mice model, through sustained release of selenite ions. The selenite ions released from the nanoparticles through a degradation-mediated fashion inhibit tumor metastasis. Blood routine analysis indicates that selenite ions can also improve the functions of liver, kidney, and heart.

KEYWORDS:

bone minerals; hydroxyapatite; nanoparticles; osteosarcoma; selenite

PMID:
26101804
PMCID:
PMC4551614
DOI:
10.1002/adhm.201500307
[Indexed for MEDLINE]
Free PMC Article

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