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J Biol Chem. 2015 Aug 7;290(32):19471-7. doi: 10.1074/jbc.R115.654764. Epub 2015 Jun 22.

Integrated Approaches for Genome-wide Interrogation of the Druggable Non-olfactory G Protein-coupled Receptor Superfamily.

Author information

1
From the Department of Pharmacology, University of North Carolina Chapel Hill School of Medicine, Chapel Hill, North Carolina 27514 bryan_roth@med.unc.edu.
2
From the Department of Pharmacology, University of North Carolina Chapel Hill School of Medicine, Chapel Hill, North Carolina 27514.

Abstract

G-protein-coupled receptors (GPCRs) are frequent and fruitful targets for drug discovery and development, as well as being off-targets for the side effects of a variety of medications. Much of the druggable non-olfactory human GPCR-ome remains under-interrogated, and we present here various approaches that we and others have used to shine light into these previously dark corners of the human genome.

KEYWORDS:

G-protein-coupled receptor (GPCR); chemical biology; cheminformatics; disease; druggable genome; functional genomics; molecular pharmacology; neurological disease

PMID:
26100629
PMCID:
PMC4528112
DOI:
10.1074/jbc.R115.654764
[Indexed for MEDLINE]
Free PMC Article

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