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Eur Arch Psychiatry Clin Neurosci. 2016 Apr;266(3):281-4. doi: 10.1007/s00406-015-0611-3. Epub 2015 Jun 23.

Increased brain-derived neurotrophic factor (BDNF) protein concentrations in mice lacking brain serotonin.

Author information

1
Department of Psychiatry and Psychotherapy, Campus Charité Mitte, Charité - University Medicine Berlin, Berlin, Germany.
2
Research Team 'Cardiovascular Hormones and Peptides', Max-Delbruck-Center for Molecular Medicine (MDC), Robert-Roessle-Str. 10, 13125, Berlin, Germany.
3
School of Physiology and Pharmacology, University of Bristol, Bristol, UK.
4
Department of Neurology, Charité - University Medicine Berlin, Berlin, Germany.
5
Research Team 'Cardiovascular Hormones and Peptides', Max-Delbruck-Center for Molecular Medicine (MDC), Robert-Roessle-Str. 10, 13125, Berlin, Germany. friederike.klempin@mdc-berlin.de.

Abstract

The interplay between BDNF signaling and the serotonergic system remains incompletely understood. Using a highly sensitive enzyme-linked immunosorbent assay, we studied BDNF concentrations in hippocampus and cortex of two mouse models of altered serotonin signaling: tryptophan hydroxylase (Tph)2-deficient (Tph2 (-/-)) mice lacking brain serotonin and serotonin transporter (SERT)-deficient (SERT(-/-)) mice lacking serotonin re-uptake. Surprisingly, hippocampal BDNF was significantly elevated in Tph2 (-/-) mice, whereas no significant changes were observed in SERT(-/-) mice. Furthermore, BDNF levels were increased in the prefrontal cortex of Tph2 (-/-) but not of SERT(-/-) mice. Our results emphasize the interaction between serotonin signaling and BDNF. Complete lack of brain serotonin induces BDNF expression.

KEYWORDS:

Antidepressant; BDNF; Depression; SERT; Serotonin; TPH2

PMID:
26100147
DOI:
10.1007/s00406-015-0611-3
[Indexed for MEDLINE]
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