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Trends Neurosci. 2015 Jul;38(7):428-38. doi: 10.1016/j.tins.2015.05.008. Epub 2015 Jun 19.

The ubiquitous nature of multivesicular release.

Author information

1
Department of Neurobiology and Evelyn McKnight Brain Institute, University of Alabama at Birmingham, Birmingham, AL 35294, USA. Electronic address: stephanie_rudolph@hms.harvard.edu.
2
Department of Neurobiology and Evelyn McKnight Brain Institute, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
3
The Vollum Institute, Oregon Health and Science University, Portland, OR 97239, USA.
4
Department of Neurobiology and Evelyn McKnight Brain Institute, University of Alabama at Birmingham, Birmingham, AL 35294, USA. Electronic address: jwadiche@uab.edu.

Abstract

'Simplicity is prerequisite for reliability' (E.W. Dijkstra [1]) Presynaptic action potentials trigger the fusion of vesicles to release neurotransmitter onto postsynaptic neurons. Each release site was originally thought to liberate at most one vesicle per action potential in a probabilistic fashion, rendering synaptic transmission unreliable. However, the simultaneous release of several vesicles, or multivesicular release (MVR), represents a simple mechanism to overcome the intrinsic unreliability of synaptic transmission. MVR was initially identified at specialized synapses but is now known to be common throughout the brain. MVR determines the temporal and spatial dispersion of transmitter, controls the extent of receptor activation, and contributes to adapting synaptic strength during plasticity and neuromodulation. MVR consequently represents a widespread mechanism that extends the dynamic range of synaptic processing.

PMID:
26100141
PMCID:
PMC4495900
DOI:
10.1016/j.tins.2015.05.008
[Indexed for MEDLINE]
Free PMC Article

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