Inhibition of Cancer Cell Migration by Multiwalled Carbon Nanotubes

Adv Healthc Mater. 2015 Aug 5;4(11):1640-4. doi: 10.1002/adhm.201500252. Epub 2015 Jun 11.

Abstract

Inhibiting cancer cell migration and infiltration to other tissues makes the difference between life and death. Multiwalled carbon nanotubes (MWCNTs) display intrinsic biomimetic properties with microtubules, severely interfering with the function of these protein filaments during cell proliferation, triggering cell death. Here it is shown MWCNTs disrupt the centrosomal microtubule cytoskeletal organization triggering potent antimigratory effects in different cancer cells.

Keywords: biomechanics; cancer; cytoskeleton; metastasis; tubulin polymers.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biocompatible Materials / chemistry*
  • Biocompatible Materials / toxicity
  • Cell Line, Tumor
  • Cell Movement / drug effects
  • Cell Proliferation / drug effects
  • HeLa Cells
  • Humans
  • MCF-7 Cells
  • Microscopy, Confocal
  • Microtubules
  • Nanotubes, Carbon / chemistry*
  • Nanotubes, Carbon / toxicity
  • Neoplasms / metabolism
  • Neoplasms / pathology
  • Spectrum Analysis, Raman

Substances

  • Biocompatible Materials
  • Nanotubes, Carbon