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J Clin Pharmacol. 2015 Dec;55(12):1313-31. doi: 10.1002/jcph.563. Epub 2015 Jul 30.

Enzyme- and transporter-mediated beverage-drug interactions: An update on fruit juices and green tea.

Author information

1
Department of Pharmaceutical Sciences and Experimental Therapeutics, College of Pharmacy, University of Iowa, Iowa City, IA, USA.
2
Department of Pharmaceutics, College of Pharmacy, University of Florida, Gainesville, FL, USA.
3
Department of Pharmacotherapy and Translational Research, College of Pharmacy, University of Florida, Gainesville, FL, USA.

Abstract

Beverage-drug interactions have remained an active area of research and have been the subject of extensive investigations in the past 2 decades. The known mechanisms of clinically relevant beverage-drug interactions include modulation of the activity of cytochrome P450 (CYP) 3A and organic anion-transporting polypeptide (OATP). For CYP3A-mediated beverage-drug interaction, the in vivo CYP3A inhibitory effect is limited to grapefruit juice (GFJ), which increases the bioavailability of several orally administered drugs that undergo extensive first-pass metabolism via enteric CYP3A. In contrast, clinically significant OATP-mediated beverage-drug interactions have been observed with not only GFJ but also orange juice, apple juice, and, most recently, green tea. Fruit juices and green tea are all a mixture of a large number of constituents. The investigation of specific constituent(s) responsible for the enzyme and/or transporter inhibition remains an active area of research, and many new findings have been obtained on this subject in the past several years. This review highlights the multiple mechanisms through which beverages can alter drug disposition and provides an update on the new findings of beverage-drug interactions, with a focus on fruit juices and green tea.

KEYWORDS:

Beverage-drug interaction; Clinical Pharmacology (CPH); Fruit juices; Green tea; OATP; Pharmacokinetics and drug metabolism

PMID:
26095990
DOI:
10.1002/jcph.563
[Indexed for MEDLINE]

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