Format

Send to

Choose Destination
Brain Imaging Behav. 2016 Jun;10(2):497-505. doi: 10.1007/s11682-015-9418-0.

Inhibition control impairments in adolescent smokers: electrophysiological evidence from a Go/NoGo study.

Yin J1,2, Yuan K3,4,5, Feng D1,2, Cheng J1,2, Li Y1,2, Cai C1,2, Bi Y1,2, Sha S1,2, Shen X1,2, Zhang B6, Xue T7, Qin W1,2, Yu D8, Lu X7, Tian J1,2,9.

Author information

1
School of Life Science and Technology, Xidian University, Xi'an Shaanxi, 710071, People's Republic of China.
2
Engineering Research Center of Molecular and Neuro Imaging Ministry of Education, Xi'an, People's Republic of China.
3
School of Life Science and Technology, Xidian University, Xi'an Shaanxi, 710071, People's Republic of China. kyuan@xidian.edu.cn.
4
Engineering Research Center of Molecular and Neuro Imaging Ministry of Education, Xi'an, People's Republic of China. kyuan@xidian.edu.cn.
5
Inner Mongolia Key Laboratory of Pattern Recognition and Intelligent Image Processing, School of Information Engineering, Inner Mongolia University of Science and Technology, Baotou, Inner Mongolia, 014010, People's Republic of China. kyuan@xidian.edu.cn.
6
School of Mechanical, Sanjiang University, Nanjing, Jiangsu, 210012, People's Republic of China.
7
Inner Mongolia Key Laboratory of Pattern Recognition and Intelligent Image Processing, School of Information Engineering, Inner Mongolia University of Science and Technology, Baotou, Inner Mongolia, 014010, People's Republic of China.
8
Inner Mongolia Key Laboratory of Pattern Recognition and Intelligent Image Processing, School of Information Engineering, Inner Mongolia University of Science and Technology, Baotou, Inner Mongolia, 014010, People's Republic of China. fmydh1@gmail.com.
9
Institute of Automation, Chinese Academy of Sciences, Beijing, 100190, People's Republic of China.

Abstract

Smoking during adolescence may promote nicotine dependence later on in life. Therefore, it is extremely important to study the neural mechanisms of adolescent smokers. As inhibition control is emphasized in several contemporary theoretical models of addiction, in the current study, we focused on the electrophysiological evidence of inhibition control deficits in adolescent smokers. By using relatively homogenous groups of adolescent smokers (n = 18) and matched nonsmokers (n = 18), we employed event-related potentials (ERP) to investigate the N200 and P300 amplitude and latency differences during a Go/NoGo task between the adolescent smokers and nonsmokers. Relative to nonsmokers, more NoGo response errors, reduced NoGo P300 amplitude, and longer P300 latency were observed in adolescent smokers. Correlation analysis revealed that the NoGo P300 amplitudes were significantly correlated with NoGo errors in both adolescent smokers and nonsmokers. Our findings provided direct electrophysiological evidence for inhibitory control impairments in adolescent smokers. It is hoped that our results may enhance understanding of the pathology of inhibitory control in adolescent smokers.

KEYWORDS:

Adolescent smokers; Event-related potentials (ERP); Go/NoGo task; Inhibition control; N200; P300

PMID:
26093534
DOI:
10.1007/s11682-015-9418-0
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Springer
Loading ...
Support Center