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Int Immunopharmacol. 2015 Sep;28(1):264-9. doi: 10.1016/j.intimp.2015.06.007. Epub 2015 Jun 18.

Capsaicin attenuates LPS-induced inflammatory cytokine production by upregulation of LXRα.

Author information

1
Department of Anesthesiology, The Maternal and Child Health Hospital of Hunan Province, Changsha, Hunan 410008, China; Department of Anesthesiology, The Second Affiliated Hospital of University of South China, Hengyang, Hunan 421001, China.
2
Department of Anesthesiology, The Second Affiliated Hospital of University of South China, Hengyang, Hunan 421001, China.
3
Department of Anesthesiology, The Second Affiliated Hospital of University of South China, Hengyang, Hunan 421001, China. Electronic address: wdm1998@163.com.
4
Department of Anesthesiology, The Second Affiliated Hospital of University of South China, Hengyang, Hunan 421001, China. Electronic address: 253477652@qq.com.

Abstract

Here, we investigated the role of LXRα in capsaicin mediated anti-inflammatory effects. Results revealed that capsaicin inhibits LPS-induced IL-1β, IL-6 and TNF-α production in a time- and dose-dependent manner. Moreover, capsaicin increases LXRα expression through PPARγ pathway. Inhibition of LXRα activation by siRNA diminished the inhibitory action of capsaicin on LPS-induced IL-1β, IL-6 and TNF-α production. Additionally, LXRα siRNA abrogated the inhibitory action of capsaicin on p65 NF-κB protein expression. Thus, we propose that the anti-inflammatory effects of capsaicin are LXRα dependent, and LXRα may potentially link the capsaicin mediated PPARγ activation and NF-κB inhibition in LPS-induced inflammatory response.

KEYWORDS:

Capsaicin; Inflammation; LXRα; NF-κB; PPARγ

PMID:
26093270
DOI:
10.1016/j.intimp.2015.06.007
[Indexed for MEDLINE]

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