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Horm Behav. 2015 Jul;73:39-46. doi: 10.1016/j.yhbeh.2015.05.016. Epub 2015 Jun 18.

Activation of G protein-coupled estrogen receptor 1 (GPER-1) decreases fluid intake in female rats.

Author information

1
Department of Psychology, University at Buffalo SUNY, Buffalo, NY 14260, United States.
2
Department of Psychology, University at Buffalo SUNY, Buffalo, NY 14260, United States. Electronic address: danielsd@buffalo.edu.

Abstract

Estradiol (E2) decreases fluid intake in the female rat and recent studies from our lab demonstrate that the effect is at least in part mediated by membrane-associated estrogen receptors. Because multiple estrogen receptor subtypes can localize to the cell membrane, it is unclear which receptor(s) is generating the anti-dipsogenic effect of E2. The G protein-coupled estrogen receptor 1 (GPER-1) is a particularly interesting possibility because it has been shown to regulate blood pressure; many drinking-regulatory systems play overlapping roles in the control of blood pressure. Accordingly, we tested the hypothesis that activation of GPER-1 is sufficient to decrease fluid intake in female rats. In support of this hypothesis we found that treatment with the selective GPER-1 agonist G1 reduced AngII-stimulated fluid intake in OVX rats. Given the close association between food and fluid intakes in rats, and previous reports suggesting GPER-1 plays a role in energy homeostasis, we tested the hypothesis that the effect of GPER-1 on fluid intake was caused by a more direct effect on food intake. We found, however, that G1-treatment did not influence short-term or overnight food intake in OVX rats. Together these results reveal a novel effect of GPER-1 in the control of drinking behavior and provide an example of the divergence in the controls of fluid and food intakes in female rats.

KEYWORDS:

Angiotensin II; Estradiol; Estrogen; Estrogen receptor; Food intake; GPR30

PMID:
26093261
PMCID:
PMC4546888
DOI:
10.1016/j.yhbeh.2015.05.016
[Indexed for MEDLINE]
Free PMC Article

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