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Am J Physiol Lung Cell Mol Physiol. 2015 Aug 15;309(4):L360-8. doi: 10.1152/ajplung.00105.2015. Epub 2015 Jun 19.

Maternal high-fat diet is associated with impaired fetal lung development.

Author information

1
Center for Pulmonary and Vascular Biology and Division of Neonatal-Perinatal Medicine, Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas;
2
Touchstone Diabetes Center, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas; and.
3
Department of Pathology and Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas.
4
Touchstone Diabetes Center, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas; and deborah.clegg@cshs.org.

Abstract

Maternal nutrition has a profound long-term impact on infant health. Poor maternal nutrition influences placental development and fetal growth, resulting in low birth weight, which is strongly associated with the risk of developing chronic diseases, including heart disease, hypertension, asthma, and type 2 diabetes, later in life. Few studies have delineated the mechanisms by which maternal nutrition affects fetal lung development. Here, we report that maternal exposure to a diet high in fat (HFD) causes placental inflammation, resulting in placental insufficiency, fetal growth restriction (FGR), and inhibition of fetal lung development. Notably, pre- and postnatal exposure to maternal HFD also results in persistent alveolar simplification in the postnatal period. Our novel findings provide a strong association between maternal diet and fetal lung development.

KEYWORDS:

chorioamnionitis; fetal growth restriction; intrauterine growth restriction; placental inflammation; respiratory distress syndrome

PMID:
26092997
PMCID:
PMC4538234
DOI:
10.1152/ajplung.00105.2015
[Indexed for MEDLINE]
Free PMC Article

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