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Diab Vasc Dis Res. 2015 Sep;12(5):377-80. doi: 10.1177/1479164115588547. Epub 2015 Jun 19.

Cerebral autoregulation in pregnancies complicated by diabetes and overweight.

Author information

1
Department of Obstetrics and Gynaecology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, TX, USA teelkien@gmail.com.
2
Department of Cardiovascular Sciences, University of Leicester, Leicester, UK NIHR Biomedical Research Unit in Cardiovascular Sciences, Glenfield Hospital, Leicester, UK.
3
Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, TX, USA St. David's Women's Center of Texas, North Austin Maternal-Fetal Medicine, Austin, TX, USA.
4
Department of Obstetrics and Gynaecology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
5
Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, TX, USA.

Abstract

AIM:

The aim of this study was to estimate the impact of diabetes and obesity on cerebral autoregulation in pregnancy.

METHODS:

Cerebral autoregulation was evaluated in women with gestational diabetes, type 2 diabetes mellitus and/or overweight (body mass index ⩾ 25 kg m(-2)) and compared to a cohort of euglycaemic pregnant women. The autoregulation index was calculated using simultaneously recorded cerebral blood flow velocity in the middle cerebral artery and blood pressure. Autoregulation index values of 0 and 9 indicate absent and perfect autoregulation, respectively.

RESULTS:

Autoregulation index in women with either diabetes (n = 33, 6.6 ± 1.1) or overweight (n = 21, 6.7 ± 0.6) was not significantly different to that in control patients (n = 23, 6.6 ± 0.8, p = 0.96).

CONCLUSION:

Cerebral autoregulation is not impaired in pregnant women who have non-vasculopathic diabetes or overweight. This suggests that the increased risk of pre-eclampsia in diabetic and overweight women is not associated with early impaired cerebral autoregulation.

KEYWORDS:

Diabetes; cerebral autoregulation; overweight; pre-eclampsia; pregnancy

PMID:
26092823
DOI:
10.1177/1479164115588547
[Indexed for MEDLINE]

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