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Eur J Pharmacol. 2015 Aug 15;761:345-52. doi: 10.1016/j.ejphar.2015.06.019. Epub 2015 Jun 16.

Trace amine-associated receptor 1: A promising target for the treatment of psychostimulant addiction.

Author information

1
Department of Pharmacology and Toxicology, University at Buffalo, Buffalo, NY, USA; Department of Physiology and Pathophysiology, Tianjin Me dical University, Tianjin, China.
2
Department of Pharmacology and Toxicology, University at Buffalo, Buffalo, NY, USA. Electronic address: junxuli@buffalo.edu.

Abstract

Abuse of and addiction to psychostimulants remains a challenging clinical issue; yet no effective pharmacotherapy is available. Trace amine associated receptor 1 (TAAR 1) is increasingly recognized as a novel drug target that participates in the modulation of drug abuse. This review analyzed existing preclinical evidence from electrophysiological, biochemical to behavioral aspects regarding the functional interactions between TAAR 1 and dopaminergic system. TAAR 1 knockout mice demonstrate increased sensitivity to dopaminergic activation while TAAR 1 agonists reduce the neurochemical effects of cocaine and amphetamines, attenuate abuse- and addiction-related behavioral effects of cocaine and methamphetamine. It is concluded that TAAR 1 activation functionally modulates the dopaminergic activity and TAAR 1 agonists appear to be promising pharmacotherapies against psychostimulant addiction.

KEYWORDS:

Addiction; Behavior; Cocaine; Methamphetamine; TAAR 1

PMID:
26092759
PMCID:
PMC4532615
DOI:
10.1016/j.ejphar.2015.06.019
[Indexed for MEDLINE]
Free PMC Article

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