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Food Chem Toxicol. 2015 Sep;83:103-10. doi: 10.1016/j.fct.2015.06.005. Epub 2015 Jun 16.

Aggregate exposure modelling of zinc pyrithione in rinse-off personal cleansing products using a person-orientated approach with market share refinement.

Author information

1
The Procter and Gamble Company, P&G Technical Centres Ltd., Whitehall Lane, Egham, Surrey, TW20 9NW, United Kingdom. Electronic address: tozer.sa@pg.com.
2
Creme Global Ltd, The Tower, Trinity Enterprise Centre, Grand Canal Quay, Dublin 2, Ireland. Electronic address: seamus.kelly@cremeglobal.com.
3
Creme Global Ltd, The Tower, Trinity Enterprise Centre, Grand Canal Quay, Dublin 2, Ireland. Electronic address: cian.omahony@cremeglobal.com.
4
Creme Global Ltd, The Tower, Trinity Enterprise Centre, Grand Canal Quay, Dublin 2, Ireland. Electronic address: dalyej@gmail.com.
5
The Procter and Gamble Company, Cincinnati, OH 45202, USA. Electronic address: nash.jf@pg.com.

Abstract

Realistic estimates of chemical aggregate exposure are needed to ensure consumer safety. As exposure estimates are a critical part of the equation used to calculate acceptable "safe levels" and conduct quantitative risk assessments, methods are needed to produce realistic exposure estimations. To this end, a probabilistic aggregate exposure model was developed to estimate consumer exposure from several rinse off personal cleansing products containing the anti-dandruff preservative zinc pyrithione. The model incorporates large habits and practices surveys, containing data on frequency of use, amount applied, co-use along with market share, and combines these data at the level of the individual based on subject demographics to better estimate exposure. The daily-applied exposure (i.e., amount applied to the skin) was 3.79 mg/kg/day for the 95th percentile consumer. The estimated internal dose for the 95th percentile exposure ranged from 0.01-1.29 μg/kg/day after accounting for retention following rinsing and dermal penetration of ZnPt. This probabilistic aggregate exposure model can be used in the human safety assessment of ingredients in multiple rinse-off technologies (e.g., shampoo, bar soap, body wash, and liquid hand soap). In addition, this model may be used in other situations where refined exposure assessment is required to support a chemical risk assessment.

KEYWORDS:

Aggregate exposure; Probabilistic modelling; Zinc pyrithione

PMID:
26092325
DOI:
10.1016/j.fct.2015.06.005
[Indexed for MEDLINE]

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