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Trends Immunol. 2015 Jul;36(7):410-8. doi: 10.1016/j.it.2015.05.005. Epub 2015 Jun 17.

T follicular regulatory cells in the regulation of B cell responses.

Author information

1
Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115, USA; Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, MA, USA.
2
Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115, USA; Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, MA, USA; Department of Pathology, Brigham and Women's Hospital, Boston, MA 02115, USA. Electronic address: Arlene_Sharpe@hms.harvard.edu.

Abstract

High affinity antibodies result from interactions between B cells and T follicular helper (Tfh) cells in germinal centers (GCs). Recent studies have identified an effector subset of T regulatory cells termed T follicular regulatory (Tfr) cells that specifically controls GC responses by suppressing Tfh and B cells. The discovery of Tfr cells has shed new light on pathways regulating humoral immunity that enable potent and specific responses to pathogens while restricting autoimmunity. Here, we review the current understanding of the cellular and molecular mechanisms underlying the differentiation and function of Tfr cells. In this context we discuss recent insights into the role of Tfh cells in disease, how this knowledge may be translated therapeutically, and important areas of further research.

KEYWORDS:

Tfh; Tfr; germinal center; humoral immunity; regulatory T cells; vaccination

PMID:
26091728
PMCID:
PMC4508020
DOI:
10.1016/j.it.2015.05.005
[Indexed for MEDLINE]
Free PMC Article

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